Pttg1^tm1Pzg
Targeted Allele Detail

Summary

• Symbol: Pttg1^tm1Pzg
• Name: pituitary tumor-transforming gene 1; targeted mutation 1, Pumin Zhang
• MGI ID: MGI:3711120
• Gene: Pttg1 Location: Chr11:43311077-43317078 bp, - strand Genetic Position: Chr11, 25.68 cM
• Alliance: Pttg1^tm1Pzg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121688
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A kanamycin resistance gene and neomycin resistance cassette replaced exons 1 and 2. Northern blot confirmed the absence of transcript in mutant cells. (J:121688)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pttg1 Mutation: 16 strains or lines available

References

• Original: J:121688 Mei J, et al., Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Curr Biol. 2001 Aug 7;11(15):1197-201
• All: 4 reference(s)