Fh1^tm1.1Pjp
Targeted Allele Detail

Summary

• Symbol: Fh1^tm1.1Pjp
• Name: fumarate hydratase 1; targeted mutation 1.1, Patrick J Pollard
• MGI ID: MGI:3711129
• Synonyms: Fh1^-
• Gene: Fh1 Location: Chr1:175428944-175453201 bp, - strand Genetic Position: Chr1, 81.58 cM
• Alliance: Fh1^tm1.1Pjp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120969
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Mice with the floxed Fh1 allele were crossed with cre-expressing mice to delete the floxed exons 2 and 3. (J:120969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fh1 Mutation: 37 strains or lines available

References

• Original: J:120969 Pollard PJ, et al., Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell. 2007 Apr;11(4):311-9
• All: 5 reference(s)