Akap6^tm1Jsco
Targeted Allele Detail

Summary

• Symbol: Akap6^tm1Jsco
• Name: A kinase anchor protein 6; targeted mutation 1, John D Scott
• MGI ID: MGI:3711141
• Synonyms: mAKAP alpha^-
• Gene: Akap6 Location: Chr12:52746166-53202382 bp, + strand Genetic Position: Chr12, 22.18 cM
• Alliance: Akap6^tm1Jsco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121227
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 2 with an IRES, LacZ, URA and neomycin cassette and thus inhibit the production of the alpha alternative transcript. (J:121227)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Akap6 Mutation: 113 strains or lines available

References

• Original: J:121227 Michel JJ, et al., Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha. Mol Cell. 2005 Dec 9;20(5):661-72
• All: 1 reference(s)