Zbtb7a^tm2Ppp
Targeted Allele Detail

Summary

• Symbol: Zbtb7a^tm2Ppp
• Name: zinc finger and BTB domain containing 7a; targeted mutation 2, Pier Paolo Pandolfi
• MGI ID: MGI:3711163
• Synonyms: Lrf^flox, Zbtb7a^flox
• Gene: Zbtb7a Location: Chr10:80971113-80988056 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband B5.3
• Alliance: Zbtb7a^tm2Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121576
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1. An frt-neo-frt-loxP cassette was inserted into intron 2. Crossing with mice expressing flp recombinase removed the neo, leaving exon 2 flanked with loxP sites. (J:121576)

Tumor Data

List all tumor models in MMHCdb carrying Zbtb7a^tm2Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb7a Mutation: 64 strains or lines available

References

• Original: J:121576 Maeda T, et al., Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science. 2007 May 11;316(5826):860-6
• All: 17 reference(s)