Tmem158^tm1Srn
Targeted Allele Detail

Summary

• Symbol: Tmem158^tm1Srn
• Name: transmembrane protein 158; targeted mutation 1, Manuel Serrano
• MGI ID: MGI:3711170
• Synonyms: Ris1^-
• Gene: Tmem158 Location: Chr9:123088118-123089829 bp, - strand Genetic Position: Chr9, 73.92 cM
• Alliance: Tmem158^tm1Srn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121067
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the ORF with a neo cassette. RT-PCR confirmed absence of transcript in brain, spleen and kindney samples from mutants. (J:121067)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem158 Mutation: 14 strains or lines available

References

• Original: J:121067 Nieto M, et al., Normal cellular senescence and cancer susceptibility in mice genetically deficient in Ras-induced senescence-1 (Ris1). Oncogene. 2007 Mar 15;26(12):1673-80
• All: 1 reference(s)