Cxadr^tm1Mds
Targeted Allele Detail

Summary

• Symbol: Cxadr^tm1Mds
• Name: coxsackie virus and adenovirus receptor; targeted mutation 1, Michael D Schneider
• MGI ID: MGI:3711225
• Synonyms: Car^F
• Gene: Cxadr Location: Chr16:78098377-78156662 bp, + strand Genetic Position: Chr16, 45.28 cM, cytoband C
• Alliance: Cxadr^tm1Mds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121400
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites. This exon encodes part of the secretion signal sequence as well as much of the extracellular immunoglobulin-like domain 1. Deletion of this exon results in a frame shift and premature termination. A frt-flanked neo was included in the vector. (J:121400)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxadr Mutation: 15 strains or lines available

References

• Original: J:121400 Chen JW, et al., Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circ Res. 2006 Apr 14;98(7):923-30
• All: 3 reference(s)