Kat2a^tm2Roth
Targeted Allele Detail

Summary

• Symbol: Kat2a^tm2Roth
• Name: K(lysine) acetyltransferase 2A; targeted mutation 2, Sharon Y R Dent
• MGI ID: MGI:3711317
• Synonyms: Gcn5^hat
• Gene: Kat2a Location: Chr11:100595572-100603291 bp, - strand Genetic Position: Chr11, 63.53 cM
• Alliance: Kat2a^tm2Roth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121357
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• The E568A mutation was introduced into exon 12 and D609A was introduced into exon 13. (J:121357)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kat2a Mutation: 40 strains or lines available

References

• Original: J:121357 Bu P, et al., Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol. 2007 May;27(9):3405-16
• All: 4 reference(s)