Cmah^tm1Ykoz
Targeted Allele Detail

Summary

• Symbol: Cmah^tm1Ykoz
• Name: cytidine monophospho-N-acetylneuraminic acid hydroxylase; targeted mutation 1, Yasunori Kozutsumi
• MGI ID: MGI:3711330
• Synonyms: Cmah^-
• Gene: Cmah Location: Chr13:24511387-24661272 bp, + strand Genetic Position: Chr13, 10.34 cM, cytoband A3.2
• Alliance: Cmah^tm1Ykoz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121365
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a neo into the second coding exon. Western blot failed to detect protein in mutants. (J:121365)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cmah Mutation: 37 strains or lines available

References

• Original: J:121365 Naito Y, et al., Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol. 2007 Apr;27(8):3008-22
• All: 10 reference(s)