Sctr^tm1Bkcc
Targeted Allele Detail

Summary

• Symbol: Sctr^tm1Bkcc
• Name: secretin receptor; targeted mutation 1, Billy K C Chow
• MGI ID: MGI:3711348
• Synonyms: Sctr^-
• Gene: Sctr Location: Chr1:119934710-119991269 bp, + strand Genetic Position: Chr1, 52.57 cM
• Alliance: Sctr^tm1Bkcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121376
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 10, which encodes the third endoloop, was replaced with a PGK-neo cassette by homologous recombination. The loss of exon 10 resulted in a frameshift, thereby introducing a premature stop codon. The mutation is expected to be a null. (J:121376)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sctr Mutation: 27 strains or lines available

References

• Original: J:121376 Chu JY, et al., Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption. Mol Cell Biol. 2007 Apr;27(7):2499-511
• All: 11 reference(s)