Sh3bp2^tm1Rtpl
Targeted Allele Detail

Summary

• Symbol: Sh3bp2^tm1Rtpl
• Name: SH3-domain binding protein 2; targeted mutation 1, Robert Rottapel
• MGI ID: MGI:3711412
• Synonyms: 3BP2^-
• Gene: Sh3bp2 Location: Chr5:34683182-34720985 bp, + strand Genetic Position: Chr5, 17.89 cM
• Alliance: Sh3bp2^tm1Rtpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121380
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace parts of exons 4 and 5 with a neomycin resistance cassette. These exons encode part of the PH domain. Western blot confirmed absence of protein in mutant splenic B Cells. (J:121380)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3bp2 Mutation: 35 strains or lines available

References

• Original: J:121380 Chen G, et al., The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response. Mol Cell Biol. 2007 Apr;27(8):3109-22
• All: 9 reference(s)