Ets1^tm1.1Dds
Targeted Allele Detail

Summary

• Symbol: Ets1^tm1.1Dds
• Name: E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1.1, Demetri D Spyropoulos
• MGI ID: MGI:3711457
• Synonyms: Ets1^deltaVII
• Gene: Ets1 Location: Chr9:32547517-32669116 bp, + strand Genetic Position: Chr9, 17.97 cM
• Alliance: Ets1^tm1.1Dds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121460
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon VII was removed via transient cre expression in ES cells. Western blot confirmed absence of expression of the VII isoform. (J:121460)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ets1 Mutation: 28 strains or lines available

Notes

ES cell line = TC1-10.

References

• Original: J:121460 Higuchi T, et al., Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice. Mol Cell Biol. 2007 May;27(9):3353-66
• All: 1 reference(s)