Dnmt3a^tm1.1Jae
Targeted Allele Detail

Summary

• Symbol: Dnmt3a^tm1.1Jae
• Name: DNA methyltransferase 3A; targeted mutation 1.1, Rudolf Jaenisch
• MGI ID: MGI:3711711
• Synonyms: Dnmt3a^1lox, Dnmt3a^L
• Gene: Dnmt3a Location: Chr12:3856007-3964443 bp, + strand Genetic Position: Chr12, 1.99 cM, cytoband A2-A3
• Alliance: Dnmt3a^tm1.1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121563
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The recombined allele is obtained by crossing the floxed allele with nestin-Cre mice in which cre is active in the male germline and the nervous system. The allele represents a null mutation. (J:121563)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt3a Mutation: 139 strains or lines available

References

• Original: J:121563 Nguyen S, et al., Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan. Dev Dyn. 2007 Jun;236(6):1663-76
• All: 5 reference(s)