Sorbs1^tm1Krc
Targeted Allele Detail

Summary

• Symbol: Sorbs1^tm1Krc
• Name: sorbin and SH3 domain containing 1; targeted mutation 1, Kenneth Chien
• MGI ID: MGI:3711721
• Synonyms: Sorbs1^-
• Gene: Sorbs1 Location: Chr19:40283197-40502223 bp, - strand Genetic Position: Chr19, 34.25 cM
• Alliance: Sorbs1^tm1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121762
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two exons that were common to all known variants were replaced by a neomycin resistance cassette, thereby disrupting the reading frame and rendering the gene inactive. Absence of transcript was confirmed in mutant adipose tissue, liver, muscle and heart. (J:121762)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sorbs1 Mutation: 144 strains or lines available

References

• Original: J:121762 Lesniewski LA, et al., Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007 Apr;13(4):455-62
• All: 1 reference(s)