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Col17a1tm1Shzu
Targeted Allele Detail
Summary
Symbol: Col17a1tm1Shzu
Name: collagen, type XVII, alpha 1; targeted mutation 1, Hiroshi Shimizu
MGI ID: MGI:3711776
Synonyms: Col17m-
Gene: Col17a1  Location: Chr19:47634783-47680460 bp, - strand  Genetic Position: Chr19, 40.07 cM
Alliance: Col17a1tm1Shzu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121695
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a PGK-neo cassette by homologous recombination. Northern blot confirmed absence of transcript in mutant karatinocytes, and Western blot confirmed absence of protein. (J:121695)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col17a1 Mutation:  51 strains or lines available
References
Original:  J:121695 Nishie W, et al., Humanization of autoantigen. Nat Med. 2007 Mar;13(3):378-83
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory