Idd6.3^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Idd6.3^C3H/HeJ
• Name: insulin dependent diabetes susceptibility 6.3; C3H/HeJ
• MGI ID: MGI:3711832
• QTL: Idd6.3 Location: Chr6:146330484-146954059 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers diabetes resistance compared to NOD. (J:115021)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:115021

The Idd6 (insulin dependent diabetes 6) locus on mouse Chromosome 6 was resolved into 3 distinct QTLs named Idd6a, Idd6b, and Idd6c using subcongenic lines derived from NOD (diabetes susceptible background strain) and C3H/HeJ (diabetes resistant donor strain). Diabetes incidence was tested weekly over a period of 30 weeks. In all subcongenic lines, the incidence of diabetes was significantly decreased compared to NOD controls.

Idd6a maps to an interval between D6Mit373 (147.9 Mb) and the chromosome 6 telomere (149.8 Mb).

Idd6b maps to an interval between D6Mit113 (144.4 Mb) and D6Mit294 (147.2 Mb).

Idd6c was localized to a 700 kb interval between D6Mit15 (147.3 Mb) and D6Mit373 (147.9 Mb). Transfer of splenocytes derived from congenic mice carrying Idd6c into NOD/scid mice confers increased protection against diabetes. Arntl2 (146.7 Mb) is a potential candidate gene for Idd6c. Arntl2 expression in the spleen and thymus is significantly increased in NOD.C3 congenic mice compared to NOD controls. Furthermore, several SNP polymorphisms are found between NOD and C3H/HeJ Arntl2 sequences, and putative strain-specific splice isoforms were observed. The Idd6c locus is syntenic to human Chromosome 12p11-p12.2.

References

• Original: J:115021 Hung MS, et al., Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6. Hum Mol Genet. 2006 Sep 15;15(18):2732-42
• All: 1 reference(s)