Kif11Gt(XE579)Byg
Gene trapped Allele Detail
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Symbol: |
Kif11Gt(XE579)Byg |
Name: |
kinesin family member 11; gene trap XE579, BayGenomics |
MGI ID: |
MGI:3711986 |
Synonyms: |
Eg5- |
Gene: |
Kif11 Location: Chr19:37364851-37410307 bp, + strand Genetic Position: Chr19, 32.27 cM
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Alliance: |
Kif11Gt(XE579)Byg page
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Mutant Cell Line: |
XE579 |
Germline Transmission: |
Earliest citation of germline transmission:
J:121799
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Parent Cell Line: |
Other (see notes) (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Gene trapped (Null/knockout, Reporter) |
Mutation: |
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Insertion of gene trap vector
Vector: pGT1Lxf
Vector Type: gene trap
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Mutation details: The gene trap vector containing a beta-galactosidase/neomycin gene was inserted within intron 18. RT-PCR confirmed that mutants contained a truncated mRNA resulting from the splicing of exon 18 to the beta-geo cassette using the cryptic splice site from the gene trap vector. The resulting protein is predicted to be inactive as it lacks the 129 amino acids of the tail domain.
(J:121799)
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Sequence Tags: |
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Sequence tag details (1 tag)
Tag ID |
GenBank ID |
Method |
Tag Location (trapped strand)* |
Select |
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Genome Context: |
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Genome Browser view of this mutation
42 gene trap insertions have trapped this gene
View all gene trap sequence tags in this region
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kif11 Mutation: |
61 strains or lines available
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All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
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Original: |
J:121799 Castillo A, et al., The kinesin related motor protein, Eg5, is essential for maintenance of pre-implantation embryogenesis. Biochem Biophys Res Commun. 2007 Jun 8;357(3):694-9 |
All: |
3 reference(s) |
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