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Kif11Gt(XE579)Byg
Gene trapped Allele Detail
Summary
Symbol: Kif11Gt(XE579)Byg
Name: kinesin family member 11; gene trap XE579, BayGenomics
MGI ID: MGI:3711986
Synonyms: Eg5-
Gene: Kif11  Location: Chr19:37364851-37410307 bp, + strand  Genetic Position: Chr19, 32.27 cM
Alliance: Kif11Gt(XE579)Byg page
Mutation
origin
Mutant Cell Line:  XE579
Germline Transmission:  Earliest citation of germline transmission: J:121799
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsThe gene trap vector containing a beta-galactosidase/neomycin gene was inserted within intron 18. RT-PCR confirmed that mutants contained a truncated mRNA resulting from the splicing of exon 18 to the beta-geo cassette using the cryptic splice site from the gene trap vector. The resulting protein is predicted to be inactive as it lacks the 129 amino acids of the tail domain. (J:121799)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kif11 Mutation:  61 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:121799 Castillo A, et al., The kinesin related motor protein, Eg5, is essential for maintenance of pre-implantation embryogenesis. Biochem Biophys Res Commun. 2007 Jun 8;357(3):694-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory