Ago2^Gt(XE344)Byg
Gene trapped Allele Detail

Summary

• Symbol: Ago2^Gt(XE344)Byg
• Name: argonaute RISC catalytic subunit 2; gene trap XE344, BayGenomics
• MGI ID: MGI:3711987
• Synonyms: Ago2^gt
• Gene: Ago2 Location: Chr15:72967693-73056777 bp, - strand Genetic Position: Chr15, 33.92 cM
• Alliance: Ago2^Gt(XE344)Byg page

Mutation origin

• Mutant Cell Line: XE344
• Germline Transmission: Earliest citation of germline transmission: J:121791
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The insertion of a gene trap vector downstream of exon 1 resulted in a truncated protein that had only 7 amino acids of the native protein. (J:121791)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XE344	CC183531 ; (MGI Seq Detail)	5' RACE	Chr15:73056610-73056657 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  12 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ago2 Mutation: 56 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:121791 Morita S, et al., One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics. 2007 Jun;89(6):687-696
• All: 4 reference(s)