Tg(Pax6-cre)1Zkoz
Transgene Detail

Summary

• Symbol: Tg(Pax6-cre)1Zkoz
• Name: transgene insertion 1, Zbynek Kozmik
• MGI ID: MGI:3711997
• Synonyms: LR-cre
• Transgene: Tg(Pax6-cre)1Zkoz Location: unknown
• Alliance: Tg(Pax6-cre)1Zkoz page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pax6-cre)1Zkoz expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pax6

• Mutation details: Three copies of a lens-specific element derived from Pax6 were cloned upstream of the Pax6 P0 minimal promoter. The regulatory element is known to drive expression in the presumptive lens ectoderm as well as the surrounding head ectoderm. The ectoderm enhancer and promoter fragments were used to drive expression of cre recombinase and EGFP, connected through an IRES. Mice were maintained on an FVB/N background. (J:121794)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax6 (species not specified) Summary of all recombinase alleles driven by Pax6. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:121794 Kreslova J, et al., Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis. 2007 Apr;45(4):157-68
• All: 2 reference(s)