Tpmt^tm1Rlng
Targeted Allele Detail

Summary

• Symbol: Tpmt^tm1Rlng
• Name: thiopurine methyltransferase; targeted mutation 1, Mary V Relling
• MGI ID: MGI:3712056
• Synonyms: Tpmt^-
• Gene: Tpmt Location: Chr13:47175463-47196833 bp, - strand Genetic Position: Chr13, 24.5 cM
• Alliance: Tpmt^tm1Rlng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121737
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Sequence containing exons V and VI was replaced with a neomycin resistance gene. (J:121737)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpmt Mutation: 21 strains or lines available

References

• Original: J:121737 Hartford C, et al., Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics. Cancer Res. 2007 May 15;67(10):4965-72
• All: 2 reference(s)