Pde6d^tm1.1Wbae
Targeted Allele Detail

Summary

• Symbol: Pde6d^tm1.1Wbae
• Name: phosphodiesterase 6D, cGMP-specific, rod, delta; targeted mutation 1.1, Wolfgang Baehr
• MGI ID: MGI:3712059
• Synonyms: Pde6d^-
• Gene: Pde6d Location: Chr1:86470735-86510260 bp, - strand Genetic Position: Chr1, 43.96 cM
• Alliance: Pde6d^tm1.1Wbae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2-4 were removed via cre mediated recombination. Immunoblot confirmed absence of protein in mutant retinal lysates. (J:121745)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde6d Mutation: 19 strains or lines available

References

• Original: J:121745 Zhang H, et al., Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8857-62
• All: 3 reference(s)