Tg(Camk2a-Crebbp*)1364Tabe
Transgene Detail

Summary

• Symbol: Tg(Camk2a-Crebbp*)1364Tabe
• Name: transgene insertion 1364, Ted Abel
• MGI ID: MGI:3712116
• Synonyms: CaMKIIalpha-CBPdelta1, CaMKIIalpha-FLAG-CBPdelta1, Tg(Camk2a-Crebbp)1364Tabe
• Transgene: Tg(Camk2a-Crebbp*)1364Tabe Location: unknown
• Alliance: Tg(Camk2a-Crebbp*)1364Tabe page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-Crebbp*)1364Tabe expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Crebbp (MGI:1098280)

• Mutation details: A transgenic construct was designed with a FLAG-epitope sequence tag at the amino terminus of a truncated mouse CREB-binding protein sequence (called CBPdelta1; lacking the coding sequence for amino acids 1084-2441), all flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end. This FLAG-CBPD1 sequence was then placed downstream of 8.5 kb of the mouse CaMKIIalpha promoter. The resulting 13 kb "CaMKIIalpha-FLAG-CBPdelta1" transgene was microinjected into the pronuclei of B6SJLF1 zygotes. Expression of the truncated product is restricted to the post-natal hippocampus, striatum, amygdala, and cortex. (J:121812)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:121812 Wood MA, et al., Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage. Learn Mem. 2005 Mar-Apr;12(2):111-9
• All: 1 reference(s)