Ccl12^tm1Ifc
Targeted Allele Detail

Summary

• Symbol: Ccl12^tm1Ifc
• Name: C-C motif chemokine ligand 12; targeted mutation 1, Israel F Charo
• MGI ID: MGI:3712151
• Synonyms: Ccl8/Ccl12^tm1Ifc, Mcp-2^-/Mcp-5^-
• Gene: Ccl12 Location: Chr11:81992671-81994225 bp, + strand Genetic Position: Chr11, 49.9 cM
• Alliance: Ccl12^tm1Ifc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121281
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted into the chemokine (C-C motif) ligand 12 locus. This insertion disrupted the expression of this gene as well as chemokine (C-C motif) ligand 8. (J:121281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccl12 Mutation: 16 strains or lines available

References

• Original: J:121281 Tsou CL, et al., Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest. 2007 Apr;117(4):902-9
• All: 5 reference(s)