Pou3f3^urehr2
Chemically induced Allele Detail

Summary

• Symbol: Pou3f3^urehr2
• Name: POU domain, class 3, transcription factor 3; urea phenotype 2
• MGI ID: MGI:3712282
• Synonyms: HST011, Pou3f3^L423P
• Gene: Pou3f3 Location: Chr1:42734928-42739370 bp, + strand Genetic Position: Chr1, 21.21 cM
• Alliance: Pou3f3^urehr2 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This ENU-induced mutation was isolated in a screen for increased plasma urea levels as part of the Munich ENU Mutagenesis Project. The genetic change is a recessive T-to-C mutation within the gene, leading to an L423P amino-acid substitution in the conserved homeobox domain of the encoded protein. (J:237899)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou3f3 Mutation: 12 strains or lines available

References

• Original: J:121470 Aigner B, et al., Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models. Am J Physiol Renal Physiol. 2007 May;292(5):F1560-7
• All: 3 reference(s)