Umod^urehr4
Chemically induced Allele Detail

Summary

• Symbol: Umod^urehr4
• Name: uromodulin; urea phenotype 4
• MGI ID: MGI:3712284
• Synonyms: HST001, Umod^A227T
• Gene: Umod Location: Chr7:119061931-119078485 bp, - strand Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
• Alliance: Umod^urehr4 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induces a G to A transversion at nucleotide 871 in exon 3 (NM_009470) that results in an amino acid substitution of threonine for alanine at position 227 (A227T). (J:153895)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Umod Mutation: 5 strains or lines available

References

• Original: J:121470 Aigner B, et al., Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models. Am J Physiol Renal Physiol. 2007 May;292(5):F1560-7
• All: 7 reference(s)