Irf4^tm1.1Rdf
Targeted Allele Detail

Summary

• Symbol: Irf4^tm1.1Rdf
• Name: interferon regulatory factor 4; targeted mutation 1.1, Riccardo Dalla-Favera
• MGI ID: MGI:3712352
• Synonyms: Irf4^-
• Gene: Irf4 Location: Chr13:30933209-30950959 bp, + strand Genetic Position: Chr13, 13.28 cM, cytoband A3.3
• Alliance: Irf4^tm1.1Rdf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112643
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The null allele was generated by crossing mice carrying the floxed Irf4 allele with Flpe-expressing mice to delete exons 1 and 2 and the EGFP sequence. (J:112643)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf4 Mutation: 28 strains or lines available

References

• Original: J:112643 Klein U, et al., Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol. 2006 Jul;7(7):773-82
• All: 10 reference(s)