Tg(Aqp2-cre)1Dek
Transgene Detail

Summary

• Symbol: Tg(Aqp2-cre)1Dek
• Name: transgene insertion 1, Donald E Kohan
• MGI ID: MGI:3712435
• Synonyms: AQP2-Cre
• Transgene: Tg(Aqp2-cre)1Dek Location: unknown
• Alliance: Tg(Aqp2-cre)1Dek page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Aqp2-cre)1Dek expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aqp2 (MGI:1096865)

• Mutation details: This transgene contains a 9.5 kb fragment of the mouse aquaporin 2 gene 5'-flanking region placed upstream of a Cre recombinase sequence (with SV40 nuclear localization signal at the amino terminus and an 11-amino acid epitope tag derived from Herpes simplex virus glycoprotein D located at the carboxy terminus). The aquaporin regulatory sequences drive Cre expression in the collecting ducts of the kidney and in sperm. (J:104785)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aqp2 (mouse) Summary of all recombinase alleles driven by Aqp2. Comparative matrix view of recombinase activities Alliance mouse Aqp2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:104785 Ge Y, et al., Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol. 2005 May;288(5):F912-20
• All: 33 reference(s)