Thbd^tm2Emc
Targeted Allele Detail

Summary

• Symbol: Thbd^tm2Emc
• Name: thrombomodulin; targeted mutation 2, Edward M Conway
• MGI ID: MGI:3712468
• Synonyms: TM^LeDneo
• Gene: Thbd Location: Chr2:148246391-148250108 bp, - strand Genetic Position: Chr2, 73.45 cM
• Alliance: Thbd^tm2Emc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118000
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The wild-type coding region was replaced with one lacking sequences encoding the N-terminal thrombomodulin domain and containing a neo cassette inserted downstream of the cytoplasmic tail. (J:118000)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbd Mutation: 25 strains or lines available

References

• Original: J:118000 Conway EM, et al., The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med. 2002 Sep 2;196(5):565-77
• All: 1 reference(s)