Pygo2^tm1.2Ssp
Targeted Allele Detail

Summary

• Symbol: Pygo2^tm1.2Ssp
• Name: pygopus 2; targeted mutation 1.2, S Steven Potter
• MGI ID: MGI:3712856
• Synonyms: Pygo2^-
• Gene: Pygo2 Location: Chr3:89337521-89342435 bp, + strand Genetic Position: Chr3, 39.12 cM
• Alliance: Pygo2^tm1.2Ssp page

Small size, eye defects and exencephaly in Pygo1^tm1.1Ssp/Pygo1^tm1.1Ssp Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp mice at E18.5

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121918
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting contruct was designed to insert loxP sites to flank exon 3, containing the PHD motif. Crossing with mice expressing cre recombinase in the germline removed exon 3 from the locus. (J:121918)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pygo2 Mutation: 24 strains or lines available

References

• Original: J:121918 Schwab KR, et al., Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol. 2007;5:15
• All: 2 reference(s)