Slc39a2^tm1Gka
Targeted Allele Detail

Summary

• Symbol: Slc39a2^tm1Gka
• Name: solute carrier family 39 (zinc transporter), member 2; targeted mutation 1, Glen K Andrews
• MGI ID: MGI:3712865
• Synonyms: Zip2^-
• Gene: Slc39a2 Location: Chr14:52130539-52134202 bp, + strand Genetic Position: Chr14, 26.71 cM
• Alliance: Slc39a2^tm1Gka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121899
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the coding region in exon 1 and 2 with GFP. RT-PCR confirmed the absence of transcript in mutants. A floxed neo included in the vector was subsequently removed via cre mediated recombination. (J:121899)

Expression

In Mice Carrying this Mutation:	61 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc39a2 Mutation: 14 strains or lines available

References

• Original: J:121899 Peters JL, et al., Targeting of the mouse Slc39a2 (Zip2) gene reveals highly cell-specific patterns of expression, and unique functions in zinc, iron, and calcium homeostasis. Genesis. 2007 Jun;45(6):339-52
• All: 2 reference(s)