Tg(Cyp11a1-cre)16Mchu
Transgene Detail

Summary

• Symbol: Tg(Cyp11a1-cre)16Mchu
• Name: transgene insertion 16, Meng-Chun Hu
• MGI ID: MGI:3712926
• Synonyms: SCC-iCre
• Transgene: Tg(Cyp11a1-cre)16Mchu Location: unknown
• Alliance: Tg(Cyp11a1-cre)16Mchu page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cyp11a1-cre)16Mchu expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Cyp11a1

• Mutation details: This transgene uses the cytochrome P450, family 11, subfamily a, polypeptide 1 promoter to drive expression of the codon-improved cre recombinase (iCre) in the adrenal cortex and gonads, as well as the diencephalons and midbrain. Two copies of the HS4 insulator sequences derived from chicken beta-globin LCR were inserted into the cassette either upstream or downstream of the construct in reverse direction. Lines 30 and 41 were also made and expressed at a similar high level and in a consistent pattern. (J:121826)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cyp11a1 (species not specified) Summary of all recombinase alleles driven by Cyp11a1. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:121826 Wu HS, et al., Human CYP11A1 promoter drives Cre recombinase expression in the brain in addition to adrenals and gonads. Genesis. 2007 Feb;45(2):59-65
• All: 6 reference(s)