Tg(Myh6-rtTA)8585Jam
Transgene Detail

Summary

• Symbol: Tg(Myh6-rtTA)8585Jam
• Name: transgene insertion 8585, John A McDonald
• MGI ID: MGI:3712947
• Synonyms: JAM8585, Tg(Myh6-rtTA)1Jam
• Transgene: Tg(Myh6-rtTA)8585Jam Location: unknown
• Alliance: Tg(Myh6-rtTA)8585Jam page

Atrial and ventricular cardiomyopathy in Tg(Myh6*/tetO-SCN5A*F1759A)#Marx/0 Tg(Myh6-rtTA)8585Jam/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: A codon optimized version (for mammalian translation) of the reverse tetracycline transactivator was cloned behind the 5.5kb alpha myosin heavy chain promoter. Reporter construct assays showed that this transgene is uniformly transcribed in cardiac myocytes, and not in various other tissues tested. (J:70619)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1  Disease Model	Tg(Myh6-rtTA)8585Jam/0 Tg(tetO-Fgfr3*R248C/Fgfr1)#Dor/0	involves: 129 * C57BL/6 * FVB/N * FVB/NTac
cx2  Disease Model	Tg(Myh6-rtTA)8585Jam/0 Tg(Myh6*/tetO-SCN5A*F1759A)#Marx/0	involves: C57BL/6 * CBA * FVB/NTac
cx3  Disease Model	Tg(Myh6-rtTA)8585Jam/0 Tg(tetO-CUGBP1)3413Coop/0	involves: FVB * FVB/N * FVB/NTac
cx4  Disease Model	Tg(Myh6-rtTA)8585Jam/0 Tg(tetO-Ppargc1a)1Dpk/0	involves: FVB/N * FVB/NTac

Phenotypes:

Affected Systems	cx1	cx2	cx3	cx4
show or hide all annotated terms
behavior/neurological	N		√
behavior/neurological phenotype	N
lethargy			√
cardiovascular system	√	√	√	√
increased cardiac muscle glycogen level		√
abnormal myocardial fiber morphology		√		√
increased myocardial fiber size	√
myocardial fiber disarray	√
myocardium necrosis			√
cardiac muscle degeneration			√
abnormal heart atrium morphology		√
increased heart atrium size		√
increased heart left atrium size		√
enlarged heart	√		√
increased heart weight			√
cardiac hypertrophy	√			√
abnormal heart ventricle morphology		√
abnormal heart left ventricle morphology			√	√
heart left ventricle outflow tract stenosis	√
dilated heart left ventricle			√	√
increased heart ventricle size		√
thick ventricular wall	√
dilated heart right ventricle				√
cardiac fibrosis		√
cardiac interstitial fibrosis	√
abnormal cardiovascular system physiology	√
decreased cardiac muscle contractility			√	√
decreased heart left ventricle muscle contractility		√
increased cardiac muscle contractility	√
increased heart left ventricle muscle contractility	√
abnormal cardiac muscle relaxation	√
decreased heart rate				√
increased heart rate				√
ventricular tachycardia		√
atrial fibrillation		√
ventricular premature beat		√
prolonged PR interval			√
prolonged QRS complex duration			√
prolonged QT interval		√
abnormal myocardial fiber currents		√
abnormal myocardial fiber sodium currents		√
cardiomyopathy	√	√		√
dilated cardiomyopathy			√
cellular	√			√
cardiac interstitial fibrosis	√
abnormal mitochondrial morphology				√
increased mitochondrial fission				√
growth/size/body	√		√	√
enlarged heart	√		√
increased heart weight			√
cardiac hypertrophy	√			√
homeostasis/metabolism		√
increased cardiac muscle glycogen level		√
mortality/aging			√
prenatal lethality			√
muscle	√	√	√	√
increased cardiac muscle glycogen level		√
abnormal myocardial fiber morphology		√		√
increased myocardial fiber size	√
myocardial fiber disarray	√
myocardium necrosis			√
cardiac muscle degeneration			√
decreased cardiac muscle contractility			√	√
decreased heart left ventricle muscle contractility		√
increased cardiac muscle contractility	√
increased heart left ventricle muscle contractility	√
abnormal cardiac muscle relaxation	√
cardiomyopathy	√	√		√
dilated cardiomyopathy			√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

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disease model

expected model not found

Models:

Human Diseases	cx1	cx2	cx3	cx4
cardiomyopathy IDs cardiomyopathy       DOID:0050700 ICD10CM:I42 ICD9CM:425 ICD9CM:425.9 MESH:D009202 NCI:C34830 NCI:C53654 UMLS_CUI:C0033141 UMLS_CUI:C0036529 UMLS_CUI:C0878544 Close				√
congestive heart failure IDs congestive heart failure       DOID:6000 DOID:395 ICD10CM:I50 ICD10CM:I50.9 ICD9CM:428 ICD9CM:428.0 ICD9CM:428.9 MESH:D006333 NCI:C3080 NCI:C50577 UMLS_CUI:C0018801 UMLS_CUI:C0018802 Close				√
dilated cardiomyopathy 1E IDs dilated cardiomyopathy 1E       DOID:0110433 ICD10CM:I42.0 OMIM:601154 Close		√
familial atrial fibrillation IDs familial atrial fibrillation       DOID:0050650 OMIM:607554 OMIM:608583 OMIM:608988 OMIM:611493 OMIM:611494 OMIM:612201 OMIM:612240 OMIM:613055 OMIM:613980 OMIM:614022 OMIM:614049 OMIM:614050 OMIM:615377 OMIM:615378 OMIM:615770 OMIM:PS608583 ORDO:334 Close		√
hypertrophic cardiomyopathy IDs hypertrophic cardiomyopathy       DOID:11984 DOID:11986 ICD9CM:425.1 ICD9CM:425.11 KEGG:05410 MESH:D002312 NCI:C34449 ORDO:217569 UMLS_CUI:C0007194 Close	√
myotonic dystrophy type 1 IDs myotonic dystrophy type 1       DOID:11722 ICD10CM:G71.11 ICD9CM:359.21 MESH:D009223 NCI:C84914 OMIM:160900 UMLS_CUI:C0027126 Close			√

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:70619 Valencik ML, et al., Codon optimization markedly improves doxycycline regulated gene expression in the mouse heart. Transgenic Res. 2001 Jun;10(3):269-75
• All: 31 reference(s)