Tg(Myh6-rtTA)8585Jam
Transgene Detail

Summary

• Symbol: Tg(Myh6-rtTA)8585Jam
• Name: transgene insertion 8585, John A McDonald
• MGI ID: MGI:3712947
• Synonyms: JAM8585, Tg(Myh6-rtTA)1Jam
• Transgene: Tg(Myh6-rtTA)8585Jam Location: unknown
• Alliance: Tg(Myh6-rtTA)8585Jam page

Atrial and ventricular cardiomyopathy in Tg(Myh6*/tetO-SCN5A*F1759A)#Marx/0 Tg(Myh6-rtTA)8585Jam/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: A codon optimized version (for mammalian translation) of the reverse tetracycline transactivator was cloned behind the 5.5kb alpha myosin heavy chain promoter. Reporter construct assays showed that this transgene is uniformly transcribed in cardiac myocytes, and not in various other tissues tested. (J:70619)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:70619 Valencik ML, et al., Codon optimization markedly improves doxycycline regulated gene expression in the mouse heart. Transgenic Res. 2001 Jun;10(3):269-75
• All: 27 reference(s)