Cryge^No3
Spontaneous Allele Detail

Summary

• Symbol: Cryge^No3
• Name: crystallin, gamma E; nuclear opacity 3
• MGI ID: MGI:3713105
• Synonyms: No3
• Gene: Cryge Location: Chr1:65087713-65090308 bp, - strand Genetic Position: Chr1, 32.8 cM
• Alliance: Cryge^No3 page

Mutation origin

• Strain of Origin: (C3H/HeH x 102/El)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Viral insertion
• Mutation details: The locus contains a murine endogenous retroviral insertion (ERVK) in exon 3, with intact LTR sequences at both ends and a duplicated GGCGGC hexamer at the insertion site. The insertion is located after codon 142 of the ORF. The mutant transcript contains a normal N-terminal domain and a normal third motif, however, the fourth motif is truncated and would not be able to complete the C-terminal domain. RT-PCR confirmed expression of the mutant transcript. (J:63651, J:121863)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cryge Mutation: 25 strains or lines available

References

• Original: J:121863 Nag N, et al., Endogenous retroviral insertion in Cryge in the mouse No3 cataract mutant. Genomics. 2007 Apr;89(4):512-20
• All: 2 reference(s)