Tg(tetO-Eda*A1)1Dsch
Transgene Detail

Summary

• Symbol: Tg(tetO-Eda*A1)1Dsch
• Name: transgene insertion 1, David Schlessinger
• MGI ID: MGI:3713107
• Synonyms: mEDA-A1
• Transgene: Tg(tetO-Eda*A1)1Dsch Location: unknown
• Alliance: Tg(tetO-Eda*A1)1Dsch page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: This transgene consists of the coding region of the mouse Eda-A1 isoform inserted between TRE/PminCMV promoter and SV40 poly A region. The tetracycline-controlled transactivator (tTA) binds to TRE and activates transcription. Expression of Eda is repressed by the addition of doxycycline and is expressed in doxycycline absence. The receptor for the Eda-A1 isoform is Edar. (J:86628)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:86628 Cui CY, et al., Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet. 2003 Nov 15;12(22):2931-40
• All: 3 reference(s)