Mfn2^tm2Dcc
Targeted Allele Detail

Summary

• Symbol: Mfn2^tm2Dcc
• Name: mitofusin 2; targeted mutation 2, David C Chan
• MGI ID: MGI:3713113
• Synonyms: Mfn2^R94Q
• Gene: Mfn2 Location: Chr4:147958056-147989161 bp, - strand Genetic Position: Chr4, 78.56 cM
• Alliance: Mfn2^tm2Dcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119702
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The R94Q mutation was inserted into the locus within the GTPase domain. A floxed neo in the vector was removed via cre mediated recombination. (J:119702)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mfn2 Mutation: 27 strains or lines available

References

• Original: J:119702 Detmer SA, et al., Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations. J Cell Biol. 2007 Feb 12;176(4):405-14
• All: 2 reference(s)