Tilss1^DBA/2NCrl
QTL Variant Detail

Summary

• QTL variant: Tilss1^DBA/2NCrl
• Name: TNF-induced lethal shock susceptibility 1; DBA/2NCrl
• MGI ID: MGI:3713355
• QTL: Tilss1 Location: unknown Genetic Position: Chr6, cM position of peak correlated region/allele: 51.53 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: DBA/2NCrl

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to TNF-induced lethal shock compared to C57BL/6JIco. (J:122128)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:77727

Linkage analysis was performed on 167 (C57BL/6 x SPRET/Ei)F1 x C57BL/6 backcross animals to identify QTLs associated with TNF hyporesponsiveness. Parental strain C57BL/6 is sensitive to the toxic effects of TNF whereas parental strain SPRET/Ei and (C57BL/6 x SPRET/Ei)F1 hybrids are resistant. At 8 weeks of age experimental animals were injected with 150 ug of TNF. This dose is lethal to C57BL/6 and 100% lethality is observed 15 to 24 hours after injection. SPRET/Ei and (C57BL/6 x SPRET/Ei)F1 hybrids do not exhibit lethality at this dose. Genome scan was performed using 69 evenly spaced microsatellite markers.

Significant linkage to TNF resistance mapped to 45 cM on mouse Chromosome 6 near D6Mit104 (P=0.00001). This locus is named Tilss1 (TNF-induced lethal shock susceptibility 1). A potential candidate gene for Tilss1 is Tnfrsf1a at 60.55 cM. A suggestive locus mapped to 15 cM on mouse Chromosome 2 near D2Mit417 (P=0.00164). A potential candidate gene for the chromosome 2 locus is Traf2.

Significant linkage to TNF sensitivity mapped to 70 cM on mouse Chromosome 11 near D11Mit333 (P=0.00009). This locus is named Tilss2 (TNF-induced lethal shock susceptibility 2).

References

• Original: J:122128 Wielockx B, et al., Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock. J Immunol. 2007 Apr 15;178(8):5069-75
• All: 1 reference(s)