Pggt1b^tm1Mbrg
Targeted Allele Detail

Summary

• Symbol: Pggt1b^tm1Mbrg
• Name: protein geranylgeranyltransferase type I, beta subunit; targeted mutation 1, Martin O Bergo
• MGI ID: MGI:3713756
• Synonyms: Pggt1b^fl
• Gene: Pggt1b Location: Chr18:46368418-46414060 bp, - strand Genetic Position: Chr18, 24.45 cM
• Alliance: Pggt1b^tm1Mbrg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122107
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites to flank exon 7, which is critical for enzymatic activity. (J:122107)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pggt1b Mutation: 27 strains or lines available

References

• Original: J:122107 Sjogren AK, et al., GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. J Clin Invest. 2007 May;117(5):1294-304
• All: 17 reference(s)