Ins2^C95S
Chemically induced Allele Detail

Summary

• Symbol: Ins2^C95S
• Name: insulin II; C95S
• MGI ID: MGI:3713760
• Synonyms: GLS004, Munich Ins2^C95S
• Gene: Ins2 Location: Chr7:142232393-142233463 bp, - strand Genetic Position: Chr7, 88.0 cM
• Alliance: Ins2^C95S page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: These mice contain a T to A transversion at nucleotide position 1903 in exon 3. This mutation caused a substitution of serine for cysteine at amino acid 95 and the loss of the A6-A11 intrachain disulfide bond. (J:122098, J:137483)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ins2 Mutation: 93 strains or lines available

References

• Original: J:122098 Herbach N, et al., Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice. Diabetes. 2007 May;56(5):1268-76
• All: 3 reference(s)