Acan^tm2Afos
Targeted Allele Detail

Summary

• Symbol: Acan^tm2Afos
• Name: aggrecan; targeted mutation 2, Amanda J Fosang
• MGI ID: MGI:3713763
• Synonyms: Jaffa
• Gene: Acan Location: Chr7:78703231-78764847 bp, + strand Genetic Position: Chr7, 44.88 cM
• Alliance: Acan^tm2Afos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122102
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: In exon 7, the nucleotide sequence GCCCTGGGC was replaced with AACGTGTAC, changing the amino acids 374ALGS to 374NVYS to eliminate the cleavage site between amino acids 373 and 374. (J:122102)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acan Mutation: 80 strains or lines available

References

• Original: J:122102 Little CB, et al., Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. J Clin Invest. 2007 Jun;117(6):1627-36
• All: 3 reference(s)