Lepr^tm2Mgmj
Targeted Allele Detail

Summary

• Symbol: Lepr^tm2Mgmj
• Name: leptin receptor; targeted mutation 2, Martin G Myers, Jr
• MGI ID: MGI:3713767
• Synonyms: Lepr^L985, Lepr^Leu985
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm2Mgmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122056
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Tyr985 was converted to a leucine in exon 18b abrogating a phosphorylation site. A Southern blot was used to confirm the conversion. (J:122056)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:122056 Bjornholm M, et al., Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest. 2007 May;117(5):1354-60
• All: 13 reference(s)