Ryr2^tm1.1Msnr
Targeted Allele Detail

Summary

• Symbol: Ryr2^tm1.1Msnr
• Name: ryanodine receptor 2, cardiac; targeted mutation 1.1, Gerhard Meissner
• MGI ID: MGI:3713774
• Synonyms: Ryr2^ADA, Ryr2^tm1Msnr
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^tm1.1Msnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122033
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert the W3587A/L3591AD/F3603A mutations into exon 75. A floxed neo was subsequently removed via cre mediated recombination. (J:122033)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 325 strains or lines available

References

• Original: J:122033 Yamaguchi N, et al., Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. J Clin Invest. 2007 May;117(5):1344-53
• All: 5 reference(s)