Serpind1^tm1Moto
Targeted Allele Detail

Summary

• Symbol: Serpind1^tm1Moto
• Name: serine (or cysteine) peptidase inhibitor, clade D, member 1; targeted mutation 1, Toshio Matsumoto
• MGI ID: MGI:3713783
• Synonyms: HCII^-
• Gene: Serpind1 Location: Chr16:17149235-17161438 bp, + strand Genetic Position: Chr16, 10.74 cM
• Alliance: Serpind1^tm1Moto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122173
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Most of exon 2 was replaced by a neomycin resistance cassette. (J:122173)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpind1 Mutation: 21 strains or lines available

References

• Original: J:122173 Aihara K, et al., Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice. J Clin Invest. 2007 Jun;117(6):1514-26
• All: 3 reference(s)