Bmp4^tm1.1Jlch
Targeted Allele Detail

Summary

• Symbol: Bmp4^tm1.1Jlch
• Name: bone morphogenetic protein 4; targeted mutation 1.1, Jan L Christian
• MGI ID: MGI:3714059
• Synonyms: Bmp4^S2G
• Gene: Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
• Alliance: Bmp4^tm1.1Jlch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108516
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Mutant mice carrying the Bmp4^tm1Jlch allele were crossed with transgenic mice expressing Cre under the control of the CMV promoter, removing the neomycin resistance cassette in the germ line, leaving the two point mutations in exon 4 and a single loxP site downstream of exon 4. (J:108516)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp4 Mutation: 23 strains or lines available

References

• Original: J:108516 Goldman DC, et al., Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity. Development. 2006 May;133(10):1933-42
• All: 4 reference(s)