Alkbh2^tm1Klng
Targeted Allele Detail

Summary

• Symbol: Alkbh2^tm1Klng
• Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase; targeted mutation 1, Arne Klungland
• MGI ID: MGI:3714064
• Synonyms: mABH2 KO
• Gene: Alkbh2 Location: Chr5:114261987-114266279 bp, - strand Genetic Position: Chr5, 55.97 cM
• Alliance: Alkbh2^tm1Klng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108782
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 3.2kb of sequence including all of exon 4. The deleted region contains the conserved 2-oxoglutarate- and Fe(II)-dependent oxygenase domain and the AlkB domain. (J:108782)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alkbh2 Mutation: 71 strains or lines available

References

• Original: J:108782 Ringvoll J, et al., Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO J. 2006 May 17;25(10):2189-98
• All: 4 reference(s)