Alkbh3^tm1Klng
Targeted Allele Detail

Summary

• Symbol: Alkbh3^tm1Klng
• Name: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase; targeted mutation 1, Arne Klungland
• MGI ID: MGI:3714065
• Synonyms: mABH3 KO
• Gene: Alkbh3 Location: Chr2:93810979-93841099 bp, - strand Genetic Position: Chr2, 51.62 cM, cytoband E1
• Alliance: Alkbh3^tm1Klng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108782
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 5.6kb of sequence, including part of exon 7 and all of exon 8. The deleted region encodes sections of the conserved 2-oxoglutarate- and Fe(II)-dependent oxygenase domain as well as the AlkB domain. (J:108782)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alkbh3 Mutation: 29 strains or lines available

References

• Original: J:108782 Ringvoll J, et al., Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA. EMBO J. 2006 May 17;25(10):2189-98
• All: 3 reference(s)