Cyld^tm1Ref
Targeted Allele Detail

Summary

• Symbol: Cyld^tm1Ref
• Name: CYLD lysine 63 deubiquitinase; targeted mutation 1, Reinhard Fassler
• MGI ID: MGI:3714113
• Synonyms: Cyld^-
• Gene: Cyld Location: Chr8:89423675-89478573 bp, + strand Genetic Position: Chr8, 43.51 cM
• Alliance: Cyld^tm1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108769
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin/lacZ cassette disrupted exon 4, which contains ATG. RT-PCR of MEFs from mutant mice did not detect transcript. (J:108769)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyld Mutation: 44 strains or lines available

References

• Original: J:108769 Massoumi R, et al., Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell. 2006 May 19;125(4):665-77
• All: 19 reference(s)