Mllt1^tm1Dw
Targeted Allele Detail

Summary

• Symbol: Mllt1^tm1Dw
• Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1; targeted mutation 1, Dennis Willerford
• MGI ID: MGI:3714136
• Gene: Mllt1 Location: Chr17:57199611-57242415 bp, - strand Genetic Position: Chr17, 29.56 cM, cytoband E1.1
• Alliance: Mllt1^tm1Dw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108588
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into exon 6 results in a stop codon and is predicted to code for a truncated protein of less than 40% of mature size. (J:108588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mllt1 Mutation: 21 strains or lines available

Notes

ES cell line = GS (Genome Systems; 129/Sv).

References

• Original: J:108588 Doty RT, et al., The leukemia-associated gene Mllt1/ENL: characterization of a murine homolog and demonstration of an essential role in embryonic development. Blood Cells Mol Dis. 2002 May-Jun;28(3):407-17
• All: 1 reference(s)