Commd1^tm1Bvds
Targeted Allele Detail

Summary

• Symbol: Commd1^tm1Bvds
• Name: COMM domain containing 1; targeted mutation 1, Bart van de Sluis
• MGI ID: MGI:3714157
• Synonyms: Commd1^-
• Gene: Commd1 Location: Chr11:22849728-22934539 bp, - strand Genetic Position: Chr11, 14.22 cM
• Alliance: Commd1^tm1Bvds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122208
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neo cassette creating a null allele. Absence of protein product was confirmed with western blot analysis. (J:122208)

Expression

In Mice Carrying this Mutation:	20 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Commd1 Mutation: 31 strains or lines available

References

• Original: J:122208 van de Sluis B, et al., Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice. Mol Cell Biol. 2007 Jun;27(11):4142-56
• All: 1 reference(s)