Maml1^tm1Mkit
Targeted Allele Detail

Summary

• Symbol: Maml1^tm1Mkit
• Name: mastermind like transcriptional coactivator 1; targeted mutation 1, Motoo Kitagawa
• MGI ID: MGI:3714162
• Synonyms: Mam1^-
• Gene: Maml1 Location: Chr11:50146461-50183138 bp, - strand Genetic Position: Chr11, 30.42 cM
• Alliance: Maml1^tm1Mkit page

Maml1^tm1Mkit/Maml1^tm1Mkit mice are growth retarded

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122286
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance cassette. This exon contains the ATG and enncodes the basic domain of the protein. (J:122286)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Maml1 Mutation: 26 strains or lines available

References

• Original: J:122286 Oyama T, et al., Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9764-9
• All: 4 reference(s)