Xylt2^tm1Meh
Targeted Allele Detail

Summary

• Symbol: Xylt2^tm1Meh
• Name: xylosyltransferase II; targeted mutation 1, Myron E Hinsdale
• MGI ID: MGI:3714171
• Synonyms: Xylt2^-
• Gene: Xylt2 Location: Chr11:94554677-94568341 bp, - strand Genetic Position: Chr11, 58.9 cM
• Alliance: Xylt2^tm1Meh page

The basement membranes of cysts in Xylt2^tm1Meh/Xylt2^tm1Meh mice resemble those of polycystic kidney disease

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122291
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-10 (94% of the coding sequence) were replaced with a neomycin resistance cassette in reverse orientation. (J:122291)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xylt2 Mutation: 29 strains or lines available

References

• Original: J:122291 Condac E, et al., Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9416-21
• All: 4 reference(s)