Zfp423^Gt(XB409)Byg
Gene trapped Allele Detail

Summary

• Symbol: Zfp423^Gt(XB409)Byg
• Name: zinc finger protein 423; gene trap XB409, BayGenomics
• MGI ID: MGI:3714339
• Synonyms: OAZ^lacZ
• Gene: Zfp423 Location: Chr8:88388438-88686223 bp, - strand Genetic Position: Chr8, 42.29 cM, cytoband C4
• Alliance: Zfp423^Gt(XB409)Byg page

Mutation origin

• Mutant Cell Line: XB409
• Germline Transmission: Earliest citation of germline transmission: J:122275
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: A gene trap vector containing a lacZ cassette was inserted into the last intron of the gene, resulting in a deletion of nine amino acids from the C-terminus and expression of a mutant fusion protein. RT-PCR confirmed expression of the mutant fusion transcript. (J:122275)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XB409	CC144407 ; (MGI Seq Detail)	5' RACE	Chr8:88413059-88506997 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  439 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp423 Mutation: 274 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:122275 Cheng LE, et al., Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis. Neuron. 2007 May 24;54(4):547-57
• All: 4 reference(s)